Scientist, In Vivo Biology
Job description
About the role
This position advances understanding of cell rejuvenation and disease reversal by testing interventions in biological systems. The scientist guides experimental strategy and partners across functions to connect measurements with physiological outcomes. You will own the design and execution of complex in vivo studies that interrogate how cellular rejuvenation mechanisms manifest at the organism level. The role requires deep engagement with cross-functional partners to ensure that biological insights are translated into rigorous experimental plans. You will drive the generation of high-quality data that reveal causal links between intervention and phenotypic change in living systems. Success in this position depends on your ability to think broadly across disciplines while maintaining precision in experimental execution. You will be a key architect of the in vivo research portfolio, shaping priorities that define the scientific trajectory of cell and regenerative biology at Altos Labs.
Key facts
What you'll do
Experimental workflows are developed and applied to map how interventions alter biological states over time in cellular and animal models.
Proficiency in these methods uncovers novel biological mechanisms.
These studies test how interventions affect tissue and organism-level phenotypes.
Collaboration with computational scientists and cross-functional teams turns complex data into clear models.
Project leadership aligns scientific questions with feasible experimental approaches.
High-quality scientific output emerges from data and interpretation. Contributions to publications, patents, and broader scientific strategy support discovery goals and long-term research.
Small rodent handling is performed with precision to support complex in vivo studies. Drug administration, tissue harvest, and processing follow strict protocols.
Physiologically relevant mouse models for chronic diseases are mastered to address key questions. Models reflect human disease mechanisms accurately.
In vivo delivery modalities such as AAV, LNP, or related systems are handled with expertise. Delivery methods are chosen based on biological and technical criteria.
Direct experience with in vivo lung, kidney, or liver disease models builds domain-specific insight. Organ-specific models reveal nuanced responses to interventions.
Ex vivo precision-cut tissue slices are generated and maintained to study tissue function. These models preserve architecture and cellular interactions.
Tissue-level genomics assays and analyses link molecular profiles with spatial and cellular context. Data integration reveals insights across scales.
Interest in studying novel biological mechanisms and emerging areas of biology fuels continuous learning. Scientists explore questions in cell and regenerative biology.
Backgrounds in aging biology, regeneration, fibrosis, inflammation, metabolic disease, neurodegeneration, or related therapeutic areas deepen context. Relevant expertise informs model selection and interpretation.
Requirements
The posting states a pay range of $127100 to $184300.
A PhD in Biology, Stem cell, Aging, Physiology, or related field provides the foundation for independent research. Relevant postdoctoral and/or industry experience strengthens this foundation.
Hands-on in vivo experience with disease mouse models is essential for executing complex studies. Disease cell and mechanistic biology expertise complements practical model work.
The ability to independently lead complex research projects from concept to execution ensures timely progress. Scientists own experimental design and interpretation.
Strong analytical skills derive biological insight from multidimensional datasets. Patterns in data reveal mechanisms that are not obvious initially.
Effective written and verbal communication conveys findings to diverse audiences. Clear communication supports collaboration and knowledge sharing.
Productive work in highly collaborative, interdisciplinary environments requires adaptability and respect. Scientists engage constructively with different perspectives and methods.
Scientific rigor, creativity, and comfort in rapidly evolving areas guide experimental choices. Curiosity drives exploration of new biological frontiers.
Nice to have
Background in aging biology, regeneration, fibrosis, inflammation, metabolic disease, neurodegeneration, or related therapeutic areas.
Direct experience with in vivo lung, kidney, or liver disease models.
Hands-on experience generating and maintaining ex vivo precision-cut tissue slices.
Experience with tissue-level genomics assays and analyses.
Good to know
The role centers on experimental biology and translating findings into living systems. Success depends on technical skill, creativity, and comfort with evolving data. Collaboration between computation and experiment drives insight. The environment values belonging, rigorous science, and continuous learning. Modern genomics methods and delivery technologies enable impactful discoveries across cell and animal models.