(Scientist) Sr. Scientist, Cardiovascular and Metabolic Disease

About the role

Flagship Pioneering, Inc. is looking for a Senior Scientist to join their research organization focused on cardiovascular and metabolic disease. The role centers on designing and leading experiments that uncover new biological insights into heart disease and metabolic disorders. The successful candidate will work from their Cambridge, Massachusetts office alongside diverse teams of researchers and business professionals. This position contributes directly to Flagship's mission of building innovative life sciences companies that address critical medical challenges. The scientist will be embedded within a collaborative environment that values rigorous inquiry, creative problem solving, and translational impact. This is an opportunity to shape research directions that may lead to meaningful therapies for patients suffering from cardiovascular and metabolic conditions. The position offers the chance to work at the intersection of fundamental biology and applied drug discovery within one of the most influential life sciences organizations in the industry.

Key facts

What you'll do

Design and lead experiments to investigate molecular mechanisms underlying cardiovascular and metabolic diseases.

Analyze large biological datasets using statistical and computational approaches to identify new therapeutic targets.

Work closely with biologists, chemists, and clinical collaborators to move discoveries toward drug development.

Communicate research results through detailed written reports and clear oral presentations to diverse audiences.

Guide and mentor junior team members on experimental design, data interpretation, and laboratory techniques.

Create and validate biological assays and disease models for testing potential therapeutic compounds.

Monitor recent scientific publications and conference proceedings to stay informed of field advancements.

Partner with academic institutions and industry organizations to validate research findings and explore joint projects.

Document research inventions and contribute to patent strategy as part of the innovation process.

Balance several active research projects at once while upholding strict standards for data integrity.

Define research hypotheses and develop experimental plans that align with broader program objectives.

Interact with external scientific advisors and regulatory experts to ensure research meets development standards.

Requirements

Hold a doctoral degree in molecular biology, biochemistry, pharmacology, or a closely related scientific area.

Possess at least five years of postdoctoral or industry research experience in cardiovascular or metabolic biology.

Have demonstrated skill in using both in vitro and in vivo models of disease.

Show a strong publication record with contributions to peer-reviewed scientific journals.

Exhibit the ability to plan and carry out complex experiments with independence and precision.

Communicate scientific concepts clearly in both written documents and spoken presentations.

Bring experience with high-throughput screening, genomic technologies, or advanced imaging methods.

Thrive in a dynamic, matrixed environment where multiple projects demand attention simultaneously.

Demonstrate deep knowledge of cardiovascular physiology or metabolic pathway biology at the molecular level.

Show a history of taking ownership of research projects from initial concept through completion.

Nice to have

Experience translating academic research findings into preclinical development stages and therapeutic candidate selection.

Knowledge of regulatory pathways and drug development milestones relevant to cardiovascular medicine applications.

Background in applying computational or machine learning methods to large-scale biological data analysis.

Previous success in establishing and directing a research project from initial concept through candidate validation.

Familiarity with venture-backed biotech environments and the pace of early-stage drug discovery programs.

Skills & tools

Proficiency in molecular and cellular biology methods such as cell culture, gene editing, and protein detection.

Hands-on experience with animal models of cardiovascular and metabolic disease for in vivo studies.

Competence with data analysis software and statistical programming environments for processing experimental results.

Familiarity with high-content imaging systems and automated screening platforms for assay development.

Working knowledge of project management and laboratory information systems for organizing research workflows.

Regular use of scientific literature databases and reference management software to track new findings.

Experience with molecular cloning, recombinant protein expression, and purification techniques is valuable.

Practical notes

This role is based at Flagship Pioneering's offices in Cambridge, Massachusetts, and requires regular on-site attendance.

The Senior Scientist will report to the research group leader overseeing cardiovascular and metabolic disease programs.

The position involves interaction with venture partners and portfolio company teams across the Flagship ecosystem.

Applicants should expect a multi-stage interview process involving both scientific and operational leadership evaluations.

The hiring timeline may extend several weeks as Flagship conducts thorough assessments of each candidate.